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保胎无忧散对小鼠诱导性流产的保胎作用

The anti-abortion effect of Bao Tai Wu You San in mice abortion induced by mifepristone

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【作者】 耿梅英翟向和赵丽娟钟秀会

【机构】 河北农业大学中兽医学院

【摘要】 本试验选择保胎无忧散预处理试验小鼠,观察保胎无忧散对米非司酮(RU486)诱导流产作用的抑制效果。试验结果表明,使用RU486在孕7d,颈部注射后,试验小鼠的流产率达到了100%;应用中药方剂保胎无忧散能有效对抗RU486诱导的小鼠流产,试验中动物模型的流产率从100%下降到40%;组织学观察,RU486诱导流产小鼠子宫内膜出现明显损伤,而在中药方剂组,试验小鼠子宫得到了有效的保护。

【Abstract】 This study attempted to identify the potential immunomodulatory and anti-abortion effect of Bao Tai Wu You San in induced abortion by mifepristone(RU486),and to examine its underlying immuno mechanism,to look for safer and less-residued drug for early embryo loss.RU486 was given via subcutaneous injection to induce abortion in mice at day 7 of gestation after received an oral gavage formular medicines everyday of gestation respectively,and pregnancy results were observed at day 7 of gestation.The mouse given RU486 via subcutaneous injection and progesterone via peritoneal injection were observed as contral meanwhile.The abortion rate of mouse given RU486 are 100%,and decrease to 40%dramatically fed Bao Tai Wu Yiu San, show its significant tocolysis effect on the abortion induced by RU486.

【关键词】 保胎无忧散流产小鼠米非司酮
【Key words】 Bao Tai Wu You Sanabortionmicemifepristone
  • 【会议录名称】 中国畜牧兽医学会动物解剖学及组织胚胎学分会第十六次学术研讨会论文集
  • 【会议名称】中国畜牧兽医学会动物解剖学及组织胚胎学分会第五次会员代表大会暨第十六次学术研讨会
  • 【会议时间】2010-08-10
  • 【会议地点】中国青海西宁
  • 【分类号】S858.91
  • 【主办单位】中国畜牧兽医学会动物解剖学与组织胚胎学分会
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