【作者】 刘书琳； 赵蔚； 张万坡； 谢敏； 王汉中； 庞代文；

【Author】 LIU Shu-ling~1,ZHAO Wei~1,ZHANG Wan-po~2,XIE Min~1,WANG Han-zhong~2 and PANG Dai-wen~(*1)(1.Key Laboratory of Analytical Chemistry for Biology and Medicine(Ministry of Education),College of Chemistry and Molecular Sciences,and State Key Laboratory of Virology,Wuhan University,Wuhan 430072;2.Wuhan Institute of Virology, Chinese Academy of Sciences,Wuhan 430072)

【机构】 武汉大学化学与分子科学学院生物医学分析化学教育部重点实验室病毒学国家重点实验室； 中国科学院武汉病毒研究所病毒学国家重点实验室；

【摘要】 建立了基于靶向纳米生物探针的禽流感活病毒快速高灵敏检测新技术,并结合单粒子示踪技术实时监测了单个禽流感病毒粒子侵染宿主细胞的动态过程。本研究不仅为国防、商检、出入境检疫、医院检验等提供准确快速的检测手段,还可为研究禽流感病毒的致病机理提供分析方法,对应对突发公共卫生事件、构筑国家公共安全体系有重要意义。更多还原

【Abstract】 Taking the advantages of novel properties of nanobioprobes,a highly sensitive method for detection of avian influenza viruses was put forward,and visualization of the viruses interacting with host cells was also realized by single particle tracking techniques.The method to detect avian influenza viruses is simple and suitable for rapid and accurate detection of viruses for the national defense,commodity inspection,customs quarantine and medical testing,which will also facilitate responding rapidly to public health emergencies and constructing a national public security system. The method for visualization of viruses by single particle tracking techniques provides a new way to explore the pathogenesis of viruses.更多还原