【作者】 刘艳； 陆晓彤； 卜书红； 田怀平； 唐跃年； 娄月芬； 张健；

【Author】 Yan Liu, Xiao-Tong Lu, Shu-Hong bu, Huai-Ping Tian, Yue-Fen Lou, Yue-Nian Tang, Jian Zhang ,* Department of pharmacy, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China

【机构】 上海交通大学医学院附属新华医院药剂科；

【摘要】 许多研究报告FASLG-844T/C基因多样性与肿瘤易感性之间的联系,但在数据上仍然存在争议。因此,需要更进一步分析以评估之间的联系。通过搜索Medline,PubMed,Embase,和WebofScience,本文作者各自独立研究了其中的数据,此项分析中包含18个发表的研究(包括22389受试者)。总的来说,等位基因-844C与肿瘤易感性的显著提高存在联系(在CC和TT之间:OR=1.23,95%CI=1.04-1.45;在CC+TC和TT之间:OR=1.15,95%CI=1.01-1.30;在CC和TT+TC之间:OR=1.20,95%CI=1.05-1.38)。在按种族分类的分组分析中,在亚洲人中发现了肿瘤易感性的显著增加(在CC和TT之间:OR=1.61,95%CI=1.37-1.89;在CC+TC和TT之间:OR=1.36,95%CI=1.16-1.60;在CC和TT+TC之间:OR=1.44,95%CI=1.22-1.70)。在研究设计的分组分析中,在基于病例对照研究的人群中发现了易感性的显著增加(在CC和TT之间:OR=1.40,95%CI=1.06-1.84;在CC+TC和TT之间:OR=1.25,95%CI=1.01-1.55;CC和TT+TC之间:OR=1.31,95%CI=1.06-1.61)。结果表明FASLG-844C等位基因正在成为癌症发展中一种低渗透癌症易感基因。然而更广泛地了解这种联系一定会在个性化预防保健这一充满希望的领域拥有广大的前景。更多还原

【Abstract】 Many studies have reported the association between the FASLG-844T/C polymorphism and cancer risk, but the data are remaining controversial. A pooled analysis was performed to assess this relationship comprehensively. Medline, PubMed, Embase, and Web of Science were searched, and data were extracted and cross-checked independently by three authors. A total of 18 published studies including 22389 subjects were involved in this analysis. Overall, the-844C allele was associated with a significantly increased cancer risk (for CC versus TT: OR = 1.23, 95% CI =1.04-1.45; for CC+TC versus TT: OR = 1.15, 95% CI = 1.01-1.30; for CC versus TT+TC: OR =1.20, 95% CI = 1.05-1.38). In the subgroup analysis by ethnicity, significantly elevated risks werefound among Asians (for CC versus TT: OR = 1.61, 95% CI = 1.37-1.89; for CC+TC versus TT: OR= 1.36, 95% CI = 1.16-1.60; for CC versus TT+TC: OR = 1.44, 95% CI = 1.22-1.70). In the subgroup analysis by study design, significantly increased risks were found among populationbased case-control studies (for CC versus TT: OR = 1.40, 95% CI = 1.06-1.84; for CC+TC versus TT: OR = 1.25, 95% CI = 1.01-1.55; for CC versus TT+TC: OR = 1.31, 95% CI = 1.06-1.61). These findings indicate that the FASLG-844C allele is emerging as a low-penetrant cancer susceptibility allele for cancer development. However, more comprehensive understanding of the association would certainly have immense prospect in the promising field of individualized preventive care.更多还原