【作者】 冯旭； 孙灵芝； 邹忠梅； 孙迪安；

【Author】 Xu Feng,Lingzhi Sun Zhong-mei Zou,Di-An Sun ~* (Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100094,China)

【机构】 中国医学科学院北京协和医学院药用植物研究所；

【摘要】 10-去乙酰巴卡亭Ⅲ是半合成抗肿瘤药物紫杉醇与多烯紫杉醇的重要中间体,而7-表-10-去乙酰巴卡亭Ⅲ是生产10-去乙酰巴卡亭Ⅲ和其他紫杉烷类化合物的副产品。将7-表-10-去乙酰巴卡亭Ⅲ转化成10-去乙酰巴卡亭Ⅲ是一个十分有用的课题。本文首次报道利用微生物将7-表-10-去乙酰巴卡亭Ⅲ转化成10-去乙酰巴卡亭Ⅲ。七种微生物可以进行转化,其转化率最高可达到70.8%。同时对其转化条件如溶剂种类,微生物种类,转化时间,底物浓度等进行了优化。更多还原

【Abstract】 7-epi-10-DeacetylbaccatinⅢ,usually considered as a by-product,could be transformed by seven microorganisms into 10-DeacetylbaccatinⅢ(10-DABⅢ),the important intermediate for the semi-synthesis of Paclitaxel and Docetaxel,at a yield as high as 70.8%.The optimized conditions such as the solvent,the microorganisms,transformation time,and substrate concentration were also investigated.更多还原