【作者】 庞振坤； 喻桂朋； 徐星； 潘春跃；

【Author】 PANG Zhen-kun,YU Gui-peng,XU Xing,PAN Chun-yue (College of Chemistry and Chemical Engineering,Central South University,Changsha 410083,China)

【机构】 中南大学化学化工学院；

【摘要】 三氟甲基磺酰基具有很强的吸电子能力,又是一种很好的离去基团,其化合物也因此被广泛地应用于有机合成中。本文以三氟甲基亚磺酸钠、苄基溴为原料,以碘化钾为催化剂,三乙基苄基溴化铵为相转移催化剂,合成了三氟甲基苄基砜。并以反应收率为主要考察指标,采用正交试验法优化了其合成条件,结果表明:以乙腈为溶剂、碘化钾为催化剂、反应温度为80℃、反应时间为12h为最佳条件。试验验证结果表明此优化条件下,反应收率达72.4%。更多还原

【Abstract】 Trifluoromethylsulfonate is widely used in organic synthesis owing to the attracting properties of trif-luoromethylsulfonyl which is one of the strongest electronegative substituents and also a good leaving group. Trifluoromethylbenzylsulfone was synthesized by the one-step reaction of sodium trifluoromethylsulfinate and benzylbromide in the presence of KI and triethylbenzylammonium bromide（TEBABR）.The synthetic procedure was optimazied by orthogonal experiments,and the optimal experiment was conducted in CH₃CN at 80℃for 12h using KI and TEBABR as catalysts.The targeted products was obtained in a high yield（72.4%） under the optimized conditions.更多还原