【作者】 徐颖； 赵东林； 赵凌云； 唐劲天；

【Author】 XU Ying~1,ZHAO Dong-lin~1,ZHAO Ling-yun~2,TANG Jin-tian~2 (1.State Key Laboratory of Chemical Resource Engineering,Beijing University of Chemical Technology,Beijing 100029,China; 2.Institute of Physics and Engineering in Medicine,Tsinghua University,Beijing 100084,China)

【机构】 北京化工大学化工资源有效利用国家重点实验室； 清华大学医学物理与工程研究所；

【摘要】 用化学共沉淀法制备了油酸钠分散的纳米Fe₃O₄水基磁流体,考察了纳米Fe₃O₄水基磁流体在交变磁场下的发热性能,对它在磁流体热疗中的应用前景进行了评价。纳米Fe₃O₄粒子的粒径为10～25nm。FT-IR光谱表明油酸钠与纳米Fe₃O₄粒子之间形成了化学吸附。在制备温度为80℃时,随着Fe²⁺:Fe³⁺比例的升高,磁流体的升温速率先升后降,当Fe²⁺:Fe³⁺>2:1时,在外加交变磁场作用下1min后,磁流体的温度>45℃,达到了医学上肿瘤治疗的发热要求。当Fe²⁺:Fe³⁺=4:1时,随着制备温度的升高,磁流体的升温速率先升后降,当制备温度>50℃时,在外加交变磁场作用下,磁流体的温度>45℃,达到了医学上肿瘤治疗的发热要求,是很有应用前景的医用纳米材料。更多还原

【Abstract】 The Fe₃O₄ nanoparticles modified by sodium oleate with diameter of 10-25 nm were prepared by coprecipitation. The inductive heating property of nano Fe₃O₄ water-based magnetic fluid in an alternating current magnetic field was investigated.The potential of the nano Fe₃O₄ water-based magnetic fluid was evaluated for tumor thermotherapy.FT-IR spectrum shows the sodium oleate was absorbed on the magnetite surface via chemical adsorption.When the coprecipitation temperature were 80℃,the inductive heating property of the nano Fe₃O₄ water-based magnetic fluids increased first and then decreased with the molar ratio of Fe²⁺ and Fe³⁺.As the molar ratio of Fe²⁺and Fe³⁺ was more than 2:1,exposed in the alternating current magnetic field for 1 min,the temperatures of the Fe₃O₄ water-based nano-magnetic fluids were higher than 45℃.When the molar ratio of Fe²⁺ and Fe³⁺ were 4:1,inductive heating property of the nano Fe₃O₄ water-based magnetic fluids increased first and then decreased with the coprecipitation temperature.As the coprecipitation.temperature was higher than 50℃,exposed in the alternating current magnetic field for 1 min,the temperatures of the Fe₃O₄ water-based nano-magnetic fluids were higher than 45℃C.The nano Fe₃O₄ water-based magnetic fluids will be useful for tumor thermotherapy.更多还原