【作者】 吴斌伟； 朱海霖； 张乐伟； 冯新星； 陈建勇；

【Author】 WU Bin-wei,ZHU Hai-lin,ZHANG Le-wei,FENG Xin-xing,CHEN Jian-yong (The Key Laboratory of Advanced Textile Materials and Manufacturing Technology of Ministry of Education, College of Materials and Textiles,Zhejiang Sci-Tech University,Hangzhou 310018,China )

【机构】 浙江理工大学"先进纺织材料与制备技术"教育部重点实验室材料与纺织学院；

【摘要】 为制备组织工程血管支架,以丝素蛋白(SF)和聚丁二酸丁二醇酯(PBS)为原料,通过静电纺丝法,以具有三维结构的收集模板取代传统的二维平板作为电纺丝收集基板,构建了丝素/PBS血管支架材料。研究了纺丝条件和三维收集模板对管状支架形貌的影响,采用FT-IR对丝素蛋白二级结构进行了表征,测试了血管支架材料的孔隙率和力学性能。结果表明,通过改变电压、纺丝间距以及三维收集模板的宏观结构,可制备出具有不同直径和长度的血管支架材料。此支架材料的孔隙率达84.6%,拉伸应力为4.31MPa,断裂伸长率为46.21%,爆破压力为358kPa。更多还原

【Abstract】 To develop a small-diameter tissue engineering blood vessel,the silk fibroin(SF)/poly(butylene succinate) (PBS) tubular scaffolds were fabricated via electrospinning.In the electrospinning process,the electrospun SF/PBS composite tubular scaffolds were collected on a 3D collector instead of traditional 2D collector. The effects of 3D collector and process parameters of electrospinning on the morphologies of the tubular scaffolds were investigated.FTIR was used to study the secondary structure of SF.The mechanical properties and the porosities of the tubular fiber materials were characterized.The results showed that SF/PBS composite tubular materials with different sizes and shapes could be prepared by changing the voltage,TCD and the structure of 3D collectors.The porosity,the tensile stress,the elongation at break and the burst pressure of the composite tubular scaffold were 84.6%,4.31MPa,46.21%and 358kPa,respectively.更多还原