【作者】 卢大胜； 汪国权； 温忆敏；

【Author】 LU Da-sheng,WANG Guo-quan,WEN Yi-min (Shanghai Municipal Center for Disease Control and Prevention,Shanghai 200336,China)

【机构】 上海市疾病预防控制中心；

【摘要】 <正>有机锡类化合物（OT）属于内分泌干扰物,可通过食物链影响人类健康。国外报道,在TBT、TPT污染严重的海域,尤其是港湾等船运发达且流水不畅的水域,常会发现软体动物假雌雄同体的雄化现象、牡蛎壳的异常增厚现象等。各国对环境和生物样品中的有机锡化合物含量进行了相关研究,并提出了一些相关分析方法。衍生化方法包括格林试剂烷基化、NaBH₄氢化和四乙基硼化钠（STEB）烷基更多还原

【Abstract】 A simple and rapid method for determination of monobutyl,dibutyl,tributyl,monophenyl,diphenyl and triphenyl in bio-matrix has been developed by C₁₈ SPE coupled with GC - MS using sodium tetraeth-ylboron as derivatization reagent.Hydrolyzation and extraction of sample were performed with 3 mol/L acetic acid containing 0.005%tropolone.The extracts were analyzed by GC - MS under SIM mode and using 1 mol/ L TPrT as an internal standard.LOD of the method was down to 10 ng/g（dry sample）,the recoveries were 56%-113%for four samples spiked at 50 ng/g with RSD of 1.0%-11.9%,and 79%-113%for four samples spiked at 200 ng/g with RSD of 0.8%- 6.5%,respectively.更多还原