25例气管癌的临床诊治分析

【作者】 杜向慧； 孙晓江； 郑远达； 裘国勤；

【机构】 浙江省肿瘤医院；

【摘要】 目的回顾性总结和分析本院1999年1月-2009年1月25例原发性气管癌的临床资料和治疗结果。方法25例原发性气管癌中,男性14例,女性11例,中位年龄49岁。从出现症状到疾病确诊的中位时间13个月(2-84月)。其中腺样囊性癌11例,鳞癌8例,腺癌3例,其他3例。治疗上单纯手术8例,单纯放疗6例,手术加放疗11例。结果全组25例的中位生存时间38个月(4～338个月),1、5、10年的局部控制率为80%、72%和56%,1、5、10年的生存率为68%(17/25)、52%(13/25)、36%(9/25)。结论原发性气管癌少见,常常延误诊断。气管癌以腺样囊性癌和鳞状细胞癌居多。手术加术后辅助放疗是原发性气管癌比较合理的治疗模式,对不能手术、肿瘤残留或术后复发的患者,放射治疗是主要的、有效的治疗手段之一。肿瘤复发后的再程治疗能增加局控和提高生存。更多还原

【Abstract】 Objective To study the efficacy of treatment in 25 patients with primary tracheal carcinoma. Methods From 1999 to 2009,25 patients with primary tracheal carcinoma treated in our hospital were retrospectively reviewed.14 were male and 11 were female with median age of 49 years.The median interval from onset of symptoms to diagnosis was 13 months(2～84 months).11 patients had adenoid cystic carcinoma, 8 patients squamous cell carcinoma,3 patients adenocarcinoma,3 patients other carcinoma.11 patients received operation plus adjuvant radiotherapy,8 received operation alone and6 received radiotherapy alone. Results The median survival time for all patients was 38 months.The 1,5,and 10 year local control rate was 80%,72%and 56%,respectively.The 1,5,and 10 year surivival rate was 68%(17/25),52%(13/25) and 36%(9/25). Conclusion Primary tracheal carcinoma is a rare disease.Early diagnosis is critical.The most common histological subtypes were adenoid cystic carcinoma and squamous cell carcinoma.Surgical resection plus adjuvant radiotherapy is a reasonable mode of treatment.The radiotherapy is still one of main and efficient treatments for inoperable cases or those patients who are recurrence or residual after surgery.Second course treatment after recurrence can raise the local controlling rate of the tumor and improve survival rate.更多还原