艾滋病患者T细胞活化与病情进展的临床研究

【作者】 岑玉文； 符林春； 姚细安； 陈谐捷； 谭行华；

【机构】 广州中医药大学热带医学研究所； 广州市第八人民医院；

【摘要】 目的探讨艾滋病患者外周血T细胞活化水平与病情进展的关系。方法观察HIV/AIDS患者105例,检测其外周血sCD27水平,CD28/CD8、CD28/CD4、HLA/CD8和CD38/CD8比例以及CD4 T淋巴细胞计数,并在正常体检人群中随机抽取15例进行对照,分析T细胞活化指标(CD28/CD8、CD28/CD4、CD38/CD8、HLA/CD8、sCD27)与疾病分期、CD4 T淋巴细胞计数的关系。结果艾滋病患者sCD27水平和HLA-DR/CD8和CD38/CD8比例较正常人显著升高,sCD27在AIDS C3期患者中明显升高,与B3期患者比较有显著性差异,CD28/CD8、HLA/CD8和CD38/CD8比例在CD4 T淋巴细胞计数>200/ul的患者中明显升高,与<200/ul的患者比较有显著性差异。结论T细胞活化水平与AIDS病情进展密切相关:艾滋病患者T细胞活化水平明显升高,在CD4 T淋巴细胞计数>200/ul患者中T细胞活化水平高于CD4 T淋巴细胞计数<200/ul。更多还原

【Abstract】 Objective This study was designed to investigate the evolvement of T cell immune activation markers on peripheral blood in patients of acquired immunodeficiency syndrome.Methods Level of sCD27,proportion of CD28/CD8,CD28/CD4,HLA/CD8,CD38/CD8 and CD4 T lymphocytes counts on peripheral blood in 105 HIV/AIDS patients was analysed,15 health blood donors was random selected as the normal control.Investigate the change of T cell immune activation level along with disease phase and CD4 T lymphocytes counts.Results Level of sCD27 and percentage of HLA-DR/CD8 and CD38/CD8 increased significantly in patients of acquired immunodeficiency syndrome.Level of sCD27 in the phase of C3 was higher than that of B3,while percentage of CD28/CD8,CD38/CD8 and HLA/CD8was higher in the patients of CD4 T lymphocytes>200/ul than those<200/ul group.Conclusion T cell immune activation level in HIV/AIDS patients was increased,especially in the patients of CD4 T lymphocytes>200/ul.It showed a correlation between T cell immune activation level and disease progress.更多还原