【作者】 赖东兰； 陈晓刚； 唐彦； 田慧； 李宜瑞；

【Author】 Donglan Lai,Xiaogang Chen,Yan Tang,Hui Tian

【机构】 广州中医药大学第一附属医院儿科；

【摘要】 目的观察益智宁煎剂对ADHD动物模型——自发性高血压大鼠(SHR)冲动行为的影响。方法按随机摸球法将大鼠分为3组:益智宁方煎药液的高剂量组、益智宁方煎药液的低剂量组和空白对照组,采用"五项选择的连续反应时间任务"(Five-choice serialreaction time task)方法检测灌药前后大鼠持续性主动注意力和冲动行为的变化情况。结果自发性高血压大鼠36只均进入结果分析。益智宁方煎剂高、低剂量组大鼠灌药后不成熟反应率分别为(5.04±1.04)%,(7.23±1.22)%,低于灌药前[(9.85±2.50)%,(9.40±1.73)%,P<0.05]及空白对照组[(9.42±1.64)%,P<0.01]。结论:益智宁方煎剂可改善SHR大鼠的冲动行为。更多还原

【Abstract】 OBJECTIVE:To observe the effect of Yizhining elixation on the impulsive behavior of spontaneous hypertensive rats. METHODS:The involved rats were randomized into 3 groups:Yizhining high dose group,Yizhining low dose group and blank control group,with 12 rats in each.Changes in sustained attention and impulsiveness of rats were detected before and after administration of Yizhining elixation by"5-choice serial reaction time task"method. RESULTS:Thirty-six spontaneous hypertensive rats were involved in the final analysis.The ratio of immature response of rats in the Yizhining high dose and low dose groups after administration was(5.04±1.04)%,(7.23±1.22)%,respectively,which was lower than that before administration[(9.85±2.50)%,(9.40±1.73)%,P<0.05]and that in the blank control group[(9.42±1.64)%,P<0.01]. CONCLUSION:Yizhining elixation can reduce the impulsive behavior of spontaneous hypertensive rats.更多还原