【作者】 熊益群； 周大桥； 姚小萍； 高辉； 吴国庆； 贺劲松； 李之清； 汪厚祥； 刘心亮； 徐绍钢；

【Author】 XIONGYi-qun~1 ZHOU Da-qiao~1 YAO Xiao-ping~1 GAO Hui~1 WU Guo-qing~2 HE Jing-song~1 LI Zhi-qing~3 WANG Hou-xiang~3 LIU Xin-liang~1 XU Shao-gang~1 1 Liver diseases section of Hospital of TCM in Shenzhen City2 Liver diseases section of Shajing Hospital in Shenzhen 3 Liver diseases section of Hubei province Hospital of TCM

【机构】 深圳市中医药研究所； 深圳市中医院； 深圳市沙井医院肝病科； 湖北省中医院肝病科；

【摘要】 目的:观察青芪散对免疫损伤小鼠的免疫调节作用。方法:中药复方制剂青芪散小、中、大3个剂量治疗冻干卡介苗(BCG)加脂多糖(LPS)免疫性肝损伤小鼠,与迈普新(Tα1)对照,观察其对淋巴细胞亚群、白细胞介素-2(IL-2)及肝脏病理的影响。结果:青芪散中剂量组显著降低CD8~+,提高CD3~+、CD4~+及CD4~-/CD8~+比值,与Tα1组比较差异有统计学意义(P<0.05);对肝组织病理学影响,中剂量组与Tα1组比较稍优,但无统计学意义(P>0.05)。结论:青芪散有明确的免疫调节作用。更多还原

【Abstract】 Objectives:To study the the Effect of Qingqi Granules on Lymphocyte Subset and Interleukin-2 of Mice.Methods:The mice Injury by bacillus calmette and Guerin(BCG) plus lipopolysaccharide(LPS) were treated by the 3 doses of Qingqi granules,control with the Thymosinα1,it was observed the effects of Qingqi granules on Lymphocyte Subset and Interleukin-2 and pathology of the mice.Results:The serum CD8~+ were significantly decreased and CD3~+、CD4~+及CD4~+/CD8~+ were significantly increased by Qingqi granules median doses than those in the control group (P<0.05).pathology changes of liver tissue were improved by Qingqi granules median doses as well as contuol group.Conclusion:Qingqi Granules have a effect of adjusting immunity clearly.更多还原