Role of the SNK-SPAR Pathway in the Development of Alzheimer’s Disease

【作者】 战丽彬；

【Author】 Libin Zhan Xiaoyang Gong Xiaoguang Lu Hua Sui Xinping Niu Zhenghong Ji Li Liu

【机构】 大连医科大学第二附属医院中医科； 大连医科大学第一附属医院中医科； 大连大学中山医院急诊室； 大连医科大学病理生理学系； 大连第二人民医院；

【摘要】 <正>Alzheimer’s disease(AD) is characterized by the presence of senile plaques and neurofibrillary tangles in the brain.The beta-amyloid protein(Aβ) is the primary constituent of the senile plaques,and has been proposed to be a key contributor to the neurodegeneration observed in AD.The molecular mechanisms underlying dendritic spine damage that is induced by Aβtoxicity in AD patients remain largely unknown.It has been suggested previously that the SNK-SPAR signaling pathway is involved in activity-dependent更多还原