【作者】 曹发昊； 欧阳五庆；

【Author】 CAO Fa-hao OUYANG Wu-qing (College of Annimal Science and Technology,Northwest A&F University,Yangling 712100,Shanxi;China)

【机构】 西北农林科技大学动物科技学院；

【摘要】 本文研究了呋喃西林纳米乳的制备,并其对抗菌活性进行研究。以橄榄油、Cremorphor RH 40、呋喃西林和蒸馏水组成纳米乳,测定其形态、粒径分布、含量、稳定性及体外抗菌活性。结果显示呋喃西林纳米乳为澄清透明液体,透射电镜下为球形液滴,平均粒径为62 nm,稳定影响因素表明其应避光低温保存,其对大肠杆菌和阴沟杆菌的抑制能力明显优于呋喃西林溶液(P<0.05),与0.4 mg/mL碘伏相比无明显差异(P>0.05)。可以看出纳米乳能增溶呋喃西林,增强其抗菌性,稳定性好,检测方法可靠。更多还原

【Abstract】 Study the preparation and invitro antibacterial activity of furacillin nanoemulsion.The nanoemulsion was prepared with the system of olive oil,furacillin,Cremorphor RH40 and distilled water.The optimum formulation of furacillin nanoemulsion was selected.The morphology,particle size distribution,furacillin content,stability and invitro antibacterial activity were studied.The furacillin nanoemulsion was a kind of clarity solution and pres- ented as small spherical drops under electron microscopy,with the average diameter of about 62 nm.The invitro antibacterial activity of furacillin nanoemulsion to E.coli and Entembacer cloacae was significantly better than fu- racillin solution(P<0.05),but there was no signigicant difference between furacillin nanoemulsion and 0.4 mg/mL iodophor disinfection solution(P>0.05).The solubility and antibacterial activity of furacillin was signifi- cantly increased in nanoemulsion.The stability of furacillin nanoemuMon was good.The method to determine con- tent was accurate and reliable.更多还原