【作者】 刘吉开；

【Author】 LIU Ji-Kai (State Key Laboratory of Phytochemistry and Plant Resource in West China,Kunming 650204)

【机构】 中国科学院昆明植物研究所植物化学与西部植物资源持续利用国家重点实验室；

【摘要】 研究了100多种中国西南高等真菌,从中分离鉴定了300多个新的天然产物包括5个新的结构骨架类型。有些显示出非常有价值的生物活性,部分侯选药物正在评价之中。本报告对其中部分活性化合物进行介绍。更多还原

【Abstract】 China is extraordinary rich in higher fungi.To date about 10,000 species of fungi have been reported from the vast territory of China.Among them,nearly 6000 species, belonging to about 1200 genera,are higher fungi(excluding lichens).Higher fungi in bio-resources belong to the very productive biologically sources which produce a large and diverse variety of secondary metabolites.We have been interested in the biologically active substances present in untapped and diverse source of higher fungi from China. In order to search for naturally occurring bioactive metabolites from higher fungi we investigated the chemical constituents of more than 100 higher fungi in Southwest of China since last 10 years.More than 300 novel terpenoids,phenolics and nitrogen-containing compounds were isolated from basidiomycetes and ascomycetes(Albatrellus confluens,Albatrellus dispansus, Boletus edulis,Boletopsis grisea,Boreostereum vibrans,Cortinarius tenuipes,Cortinarius vibratilis,Daldinia concentrica,Engleromyces gotzii,Hydnum repandum,Hygrophorus eburnesus,Lactarius deliciosus,Lactarius hirtipes,Lactarius mitissimus,Lactarius rufus, Polyporus ellisii,Russula cyanoxantha,Russula foetens,Russula lepida,Russula nigricans, Sarcodon leavagatum,Sarcodon scabrosus,Shiraia bambusicola,Suillus granulatus,Thelephora aurantiotincta,Thelephora ganbajun,Tremella aurantilba,Tricholomopsis rutilans,Tylopilus plumbeoviolaceus,Xylaria euglossa etc.).Some of them showed very interesting pharmacological activities.The isolation,structural elucidation and biologically activity of the new compounds are discussed.更多还原