【作者】 关心； 赵玉红； 平静； 王晓蕾； 李坚； 卢熠； 吴丽霞；

【Author】 Guan xin1,Zhao yuhong1,Ping jing2,Wang xiaolei 1,li jian1,Lu yi1,Wu lixia1 1 Shenzhou Hospital affiliated Shenyang Medical College,Shenyang 110002;2 Shenyang Pharmaceutical University,Shenyang 110016

【机构】 沈阳医学院沈洲医院； 沈阳药科大学药学院；

【摘要】 目的探讨Ⅱ型糖尿病患者血糖(FBG)、糖化血红蛋白(HbAlc)、胰岛素(Insulin)、C肽(CPE)测定指标之间相互关系的临床应用,同时研究了与血压、血脂的相关性。方法选择Ⅱ型糖尿病人94例,正常对照组36例。采用葡萄糖氧化酶方法、免疫透射比浊法和微粒子化学发光法分别测定FBG、HBAlc、Insulin和C肽浓度。血清胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-Ch)和低密度脂蛋白胆固醇(LDL-Ch)的测定是用常规的生化方法测定。结果Ⅱ型糖尿病中的FBG、HbAlc、Insulin和CPE明显高于正常对照组(P<0.01)。Ⅱ型糖尿病患者FBG、HbAlc与Insulin之间均呈正相关。结论由于FBG、HBAIc、Insulin和CPE数值反映了3个不同时期的FBG水平,为临床提供了一个近期纵向、全程的FBG水平信息。因此,联合测定FBG、HbAlc、Insulin和CPE对糖尿病的诊断治疗、监控预防有较高的临床应用价值。更多还原

【Abstract】 Objective:To study fasting blood glucose(FBG),glycosylated hemoglobin(HbAlc),and insulin(Ins)concentrations 3 indicators of mutual relations in patients with type 2 diabetes and the clinical application.Method:FBG,HbAle,Ins concentrations were Respectively determined by enzymatic oxidation,immunization turbidity,chemiluminescence.After treatment of the diabetic patients 1 month and 2 months,we reexamined.Results:type 2 diabetes in the FBG,HbAlc,Ins were significantly higher than the normal control group(P <0.01).Conclusion:Glucose metabolism target and Ins level relations:in impaired glucose tolerance(IGT)to the clinical early time,has been in existence Ins resistance,the relative lack of Ins can compensatory increase in the FBG to maintain the normal limit level;Clinical early to mid-FBG increased,Ins resistance gradual increase,the Ins level relative insufficiency hastens obviously,β-cell function appears from strengthens to the weaken transformation,in blood Ins levels were unstable state of fluctuation,is in the earlier decompensated period;The clinical mid and late stage,appears continues high FBG,the serious Ins resistance still existed,starts to present the Ins to be absolutely insufficient,Beta cell function is in a decompensated period or the failure time,the blood insulin level reduces unceasingly.The entire diabetes course,the typical Ins concentration curve was inverted U-shaped approximately.As FBG,HBAIc,and Ins reflects the three different periods of FBG level,to provide a recent clinical vertical,the entire process of FBG level of information to guide clinical development of treatment programmes.更多还原