2006年LC-MS在药物分析中的应用(英文摘要)

【作者】 杨腊虎； 于宝珠； 陈立亚； 赵慧芳； 陈唯真； 王子兰； 刘小帅；

【机构】 中国药品生物制品检定所；

【摘要】 <正>1:Xenobiotica.2006 Aug;36 (8):709-23. Metabolism of the recently encountered designer drug,methylone,in humans and rats. Kamata HT,Shima N,Zaitsu K,Kamata T,Miki A,Nishikawa M,Katagi M,Tsuchihashi H. Forensic Science Laboratory,Osaka Prefectural Police HQ,Osaka,Japan. The urinary metabolites of methylone in humans and rats were investigated by analysing urine specimens from its abuser and after administrating to rats with gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-electrospray ionization mass spectrometry (LC-ESI MS),using authentic standards.The time -course excretion profiles of methylone and its three metabolites in rats were further investigated after a single in- traperitoneal dosing of 5 mg kg-1 methylone hydrochloride.Two major metabolic pathways were revealed for both humans and rats as follows:(1) side-chain degradation by N-demethylation to the corresponding primary a- mine methylenedioxycathinone (MDC), partly conjugated; and (2) demethylenation followed by O-methylation of either a 3-or 4-OH group on the benzene ring to produce 4-hydroxy-3-methoxymethcathinone (HMMC) or 3-hydroxy-4-methoxymethcathinone (3-OH-4-MeO-MC),respectively,mostly conjugated.Of更多还原