【作者】 韩春然； 徐丽萍；

【Author】 Han Chunran Xu Liping (College of Food Engineering,Harbin University of Commerce,Harbin 150076)

【机构】 哈尔滨商业大学食品工程学院；

【摘要】 为明确黑木耳多糖的组分及其生理功能,以复合酶法对黑木耳多糖进行了提取,并以柱层析法对其进行了纯化；以纯化的黑木耳多糖喂饲大鼠,考察了其降血脂的功能。通过试验得到两种黑木耳多糖,即 APE Ⅰ和 APE Ⅱ；各剂量的 APE Ⅰ对大鼠体重没有显著影响； 100mg/kg 体重及以上的 APE Ⅰ可以显著降低高脂大鼠血清的 TG、TC、LDL-C 水平,提高其 HDL-C 水平；200mg/kg 体重的黑木耳多糖对高脂大鼠血清的 TG、TC、LDL-C 和 HDL-C 的影响与70mg/kg 体重的脂必妥的效果没有显著差异,并能够显著提高高脂血症大鼠的 HDL-C/TC 水平。黑木耳多糖(APE Ⅰ)具有降血脂功能,对高脂血症的发生有一定的预防作用,同时对冠心病和动脉粥样硬化也有一定的预防作用。更多还原

【Abstract】 In order to determine the polysaccharide composition and its physiological function of Auricularia auricular,combined enzymes were used to extract the polysaccharide of Auricularia auricular,which was then purified by column chromatography,and the hypolipidemia activity was studied by feed rats.Two fractions of Auricularia auricular polysaccharides(APE),APE Ⅰ and APE Ⅱ were obtained,APE Ⅰ had no obviues effect on the body weight of rats;at the dose of 100 mg/kg body weight and above,APE Ⅰ can significantly reduce the serum TC、TG and LDL-C levels and enhance the HDL-C levels in hyperlipidemia rats;at the dose of 200 mg/kg body weight,APE Ⅰ had similar effects on the levels of serum TG、TC、LDL-C and HDL-C of hyperlipidemia rats with Zhi-bi-tuo capsule(70 mg/kg body weight),and enhanced the levels of HDL-C/TC significantly.It is concluded that APE Ⅰ,one of the polysaccharides from Auricularia auricular,had hypolipidemia activity,and can prevent hyperlipemia,coronary disease and atherosclerosis.更多还原