【作者】 钱金兰； 李欣； 郭震； 刁文瑜； 徐凌峰； 吴金宝； 殷凤珍； 丁慧萍；

【Author】 QIAN Jin-lan LI Xin GUO Zhen DIAO Wen-yu XU Lin-feng WU Jin-bao YIN Feng-zhen DING Hui-ping (Department of CPB,Shanghai Chest Hospital,Shanghai 200030)

【机构】 上海市胸科医院体外循环室； 上海市胸科医院麻醉科；

【摘要】 目的:探讨6%中分子羟乙基淀粉和4%的琥珀明胶用丁体外循环预充时,对患者凝血功能的影响。方法:选择40例瓣膜替换术的患者,随机分为贺斯组和佳乐施组。分别在麻醉前及鱼精蛋白中后30分钟取静脉血 1ml,运用 Sonoclot 凝血及血小板功能分析仪测定凝血功能,测定参数有:激活凝血时间(SonACT)、凝血速率(Clot Rate)、血小板功能(Platelet Function),并描绘凝血过程曲线图。结果:两组间激活凝血时间、血小板功能术前术后均无显著性差异,但术后凝血速率贺斯组明显小于佳乐施组。结论:佳乐施与贺斯1000ml 用于预充时对凝血功能无显著影响,但与佳乐施相比,贺斯对凝血通路中纤维蛋白形成速度抑制相对较强。更多还原

【Abstract】 OBJECTIVE:To observe the effect of 6% hydroxyethel starch(HES)and 4% succinylated gelatin(GEL)for priming on coagulation in the operation with cardiopulmonary bypass(CPB).METHODS:Thirty-eight patients ondergoing valve replacement were divided randomly into two groups:Group HES and Group GEL.The SonACT,Clot Rate and Platelet Function were measured in the two groups before anaesthesia and 30 minutes after protamine were counteract with Sonoclot Analyzer.RESULTS:There is no significant difference between these two groups before and after CPB in terms of coagulation data:SonACT and Platelet Function(P>0.05),but compared with GEL groups,the Clot Rate decreased significantly after CPB(P<0.05).CONCLUSION:There is no significant effect on coagulation when 1000ml HES and GEL were used for priming,but the effect of restraining the fibrin come into being is stronger than GEL.更多还原