节点文献
Using Tandem Affinity Purification technique to Study the transcription mechanism of canonical Wnt signaling pathway
【Author】 Fei Cong Wei Wei Li Lin State Key Laboratory of Molecular Biology and Institute of Biochemistry and Cell Biology,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,Shanghai 200031,China
【摘要】 <正>The Canonical Wnt signaling pathway regulates many aspects of developmental processes in vertebrates,and plays a crucial role in several human diseases.In cells not exposed to Wnt ligands,Wnt target genes are repressed by the association of TCF/LEF with Groucho.When Wnt protein binds to its receptors,cytoplasmic beta-catenin accumulates and then translocates to the nucleus,replaces Groucho from TCF/LEF to activate Wnt target genes.However the molecular
- 【会议录名称】 第二届全国“跨学科蛋白质研究”学术讨论会论文集
- 【会议名称】第二届全国“跨学科蛋白质研究”学术讨论会
- 【会议时间】2008-07
- 【会议地点】中国山东烟台
- 【分类号】R33
- 【主办单位】中国生物化学与分子生物学学会蛋白质专业委员会（The Chinese Protein Society）