Small molecules regulate homeostasis of cytokines for suppression of pulmonary fibrosis and tumor metastasis

【作者】 梁伟；

【Author】 GangJun Du~(1,2) Lingtao Jin~1 Xiaofen Han~2 Zhihui Song~2 Hongyan Zhang~1 Wei Liang 1 Protein & Peptide Pharmaceutical Laboratory,Institute of Biophysics,Chinese Academy of Sciences,Beijing 100101,China;2 Department of Pharmacology,Pharmaceutical College of Henan University,Kaifeng 475001,China

【机构】 Protein & Peptide Pharmaceutical Laboratory,Institute of Biophysics,Chinese Academy of Sciences；

【摘要】 <正>Increasing evidence points to involvement of the fibrotic microenvironment in cancer initiation and progression. Here we demonstrate that mice with lung fibrosis challenged with tumors show an increased incidence of lung metastasis and shorter life spans.A fibrotic environment in the lung results in increased abundance of TGF-β1 and CD4+CD25+FoxP3+regulatory T cells and a decreased proportion of activated effector T cells.This grave immunosuppressive environment favors tumor localization and growth. Naringenin significantly reduces lung metastases in mice with pulmonary fibrosis and increases their survival by improving the immunosuppressive environment through downregulating TGF-β1 and reducing levels of regulatory T cells.Taken together,these data indicate that naringenin could be an ideal therapeutic agent in the treatment of both cancer and fibrosis.更多还原

【Abstract】 Increasing evidence points to involvement of the fibrotic microenvironment in cancer initiation and progression. Here we demonstrate that mice with lung fibrosis challenged with tumors show an increased incidence of lung metastasis and shorter life spans.A fibrotic environment in the lung results in increased abundance of TGF-β1 and CD4+CD25+FoxP3+regulatory T cells and a decreased proportion of activated effector T cells.This grave immunosuppressive environment favors tumor localization and growth. Naringenin significantly reduces lung metastases in mice with pulmonary fibrosis and increases their survival by improving the immunosuppressive environment through downregulating TGF-β1 and reducing levels of regulatory T cells.Taken together,these data indicate that naringenin could be an ideal therapeutic agent in the treatment of both cancer and fibrosis.更多还原