【作者】 夏维； 胡红兵； 陈和斌； 熊宝华； 陈琼； 董宗祈；

【Author】 Hu Hong-bing Xia Wei Kang Si-xiu Xiong Bao-hua Childrn Hospital of Wuhan,Wuhan 430016

【机构】 武汉市儿童医院；

【摘要】 目的动态调查分析湖北地区儿童感染大肠埃希菌的耐药性变迁趋势, 为临床合理使用抗生素提供科学依据。方法采用 WHONET4-5软件对1767株大肠埃希菌的耐药率进行统计分析。菌株分离自湖北地区17所三级医院2003～ 2006年儿章患者各类临床标本。结果儿童感染大肠埃希菌的耐药率低于成人组。4年中,该菌除对碳青霉烯类抗生素亚胺培南和美罗培南保持100%的敏感率外,对其他常用抗菌药物的耐药率多呈上升趋势,对氨苄西林耐药率最高,达 84%—90%;耐药率较低的抗菌药物有阿米卡星、头孢西丁、头孢他啶、头孢吡肟(为3%—25%)。结论湖北地区儿童感染大肠埃希菌的耐药性呈上升趋势, 应切实采取有效措施,控制耐药菌的传播与流行。更多还原

【Abstract】 Objectives To investigate dynamically antibiotic resistance changing of Escherichia coli in Hubei province and provide the reference for clinical rational application of antibiotics.Methods The WHONET4-5 software was used to analyzed the antibiotic resistant rates of 1767 strains of E.coli isolated from all kinds of clinical specimen of children from 2003 to 2006 in the third grade hospitals of Hubei province. Results Drug-resistance rate of E.coli in children group was lower than that in adult group.Except for 100% susceptibility to carbopenems such as imipenem and Meropenem,in the four years,drug-resistance of the other antibiotics showed ascending tendency.Ampicillin showed the highest drug-resistance rate(84%-90%). The lower(3%-25%)were amikacin,cefoxitin,ceftazidime,cefepime.Conclusions Antibiotic resistance of E.coli in children in Hubei province showed the ascending tendency.We should take effective measurement to control the spread and prevalence of the drug-resistant bacteria.更多还原