【作者】 李月华； 赵东林； 曾宪伟； 夏启胜； 唐劲天；

【Author】 LI Yue-hua~1 ZHAO Dong-lin~1 ZENG Xian-wei~1 XIA Qi-sheng~2 TANG Jin-tian~3 (1.State Key Laboratory of Chemical Resource Engineering,Institute of Carbon Fiber and Composites,Beijing University of Chemical Technology,Beijing 100029,China; 2.Institute of Clinical Medical Sciences,China-Japan Friendship Hospital,Beijing 100029,China; 3.School of Medicine,Tsinghua University,Beijing 100084,China)

【机构】 北京化工大学化工资源有效利用国家重点实验室,碳纤维及复合材料研究所； 中日友好医院临床医学研究所； 清华大学医学院；

【摘要】 以纳米 Fe₃O₄粒子为原料,通过空气氧化法, 制备出了具有不同磁性能的球形和立方形纳米γ-Fe₂O₃ 粒子,研究了纳米γ-Fe₂O₃粒子的磁性能及其在交变磁场下的发热性能,对其在定向集热治疗肿瘤中的应用前景进行了评价．纳米γ-Fe₂O₃粒子的比饱和磁化强度为 44．18～69．84A．m²/kg,矫顽力为（13～17）×79．6A/m。纳米γ-Fe+O+3粒子含量为20mg/ml 时,在外加交变磁场作用下15 min 后,纳米γ-Fe₂O₃粒子生理盐水悬浮液的温度为38．6～54．4℃,随着纳米γ-Fe₂O₃粒子比饱和磁化强度的增加,其在交变磁场中所达到的最高温度增大, 有3种纳米γ-Fe₂O₃粒子达到了医学上定向集热治疗肿瘤用热籽的发热要求,纳米γ-Fe₂O₃粒子是很有应用前景的医用纳米材料．更多还原

【Abstract】 The γ-Fe₂O₃ nanoparticles with different magnetic properties were prepared by oxidation of Fe₃O₄ nanoparticles in the air.The inductive heating properties of the γ-Fe₂O₃ nanoparticles in an alternating current （AC） magnetic field were investigated for local hyperthermia.The potential of the γ-Fe₂O₃ nanoparticles was evaluated for localized hyperthermia treatment of cancers.The saturation magnetization Ms and coercivity H_c of γ-Fe₂O₃ nanoparticles were 44.18-69.84 A.m²/kg and （13-17）×79.6 A/m respectively.Exposed in the AC magnetic field for 15 min,the temperatures of physiological saline suspension containing γ-Fe₂O₃ nanoparticles with concentration of 20 mg/ml were 38.6-54.4℃.The inductive heating property of γ-Fe₂O₃ nanoparticles in AC magnetic field increased with the increasing of Ms.The γ-Fe₂O₃ nanoparticles would be useful as good thermoseeds for localized hyperthermia treatment of cancers.更多还原