【作者】 鲁朝晖； 徐少保； 沈强； 赵宗豪；

【Author】 LU Zhao-hui ZHANG Qu-xia CHANG Li-Fei, Department Of Infectious Diseases,Anhui Provincial Hospital,Hefei 230001

【机构】 安徽省立医院传染科；

【摘要】 目的:探讨人工肝支持系统（ALSS）对重型肝炎的疗效。方法:应用人工肝支持系统（WLXGX-888） 对46例重型病毒性肝炎进行了104例次的治疗。根据病情分别选择血浆置换、血液灌流、血浆吸附和血液滤过4种治疗方法。比较治疗前后临床表现和血浆总胆红素（TBIL）、血氨（NH₃）、肿瘤坏死因子-α（TNF-α） 水平、凝血酶原活动度（PTA）、丙氨酸转氨酶（ALT）、白蛋白（ALB）。选择同期住院病情相近的病例40 例为对照组。结果:治疗后症状明显改善,血总胆红素（TBIL）、血氨（NH₃）、肿瘤坏死因子-α（TNF-α） 水平明显下降,凝血酶原活动度（PTA）明显上升。治疗组有效率为71。7%,对照组有效率为37.5%（p<0.05）. 人工肝支持系统治疗的不良反应在处理后均能好转。结论:人工肝支持系统治疗重型肝炎能有效改善临床症状、显著改善生化指标,降低 TNF-α水平,提高近期存活率,是一种安全可行的治疗方法。更多还原

【Abstract】 Objectives Peobing the curing effects of artificial liver supporting systems(ALSS)treatment of fatal hepatitis.Methods Use ALSS(WLXGX-888)to concluct 104 times of treatment on 46 fatal viral hepatitis cases.To compare the clinical manifestation and blood levels of TBIL,NH3,TNF-a,PTA,ALT,ALB prior to and subsequent to the treatment.The contrast group consists of 40 cases of similar patient who were admitted to the hospital during the same period of time.Results After treatment the symptoms were effectively improved.The blood level of TBIL,NH3,TNF-ashow significant clecrease and the leveal PTA increases.71.7% at effectual rate in the treatment group,but 37.5% in the contrust group.After available treatment the untoward effect takes a favorable recovery.Conclusion Artificial liver supporting systems on the treatment of fatal hepatitis can effectively improve the clinical symptoms,remarkably improve the biochemical indicators,reduce TNF-α and increase the short-term survival percentage.ALSS is indeed an effective and safe to the treatment of fatal hepatitis.更多还原