【作者】 王辰； 朱宇清； 曾庆； 孙洪涛； 支力大； 吴健敏；

【Author】 WANG chen, ZHU yuqing. Emergency Department ,China-Japan Friendship Hospital, Beijing 10029,China.

【机构】 卫生部中日友好医院急诊科；

【摘要】 目的探讨危重症人群血清胆碱酯酶(ChE)水平与APACHE Ⅱ评分的关系．方法:对116例收入EICU 24 小时内的危重患者的血清胆碱酯酶水平进行测定,并测定30例正常人的血清胆碱酯酶水平对照分析,比较两组间的差异．同时对这116例患者进行APACHEⅡ评分,按照APACHEⅡ评分分值的高低分成三组(<15分组、15-20分组、>20 分组),比较不同组别间血清胆碱酯酶水平的差异。将本组116例危重症患者按照是否死亡分为死亡组和存活组,比较两组间血清胆碱酯酶水平的差异:(1)危重症患者的血清胆碱酯酶平均水平较正常人明显降低(P<0．01)。(2)危重症患者的血清胆碱酯酶水平与其APACHEⅡ评分的分值成负相关(r=-0．2251,P<0．01),病情越危重,APACHEⅡ评分分值越高死亡率越高,相应血清胆碱酯酶水平越低下(p<0．01)．结论血清胆碱酯酶水平是反映危重症病情及评价预后的一项重要参考指标。更多还原

【Abstract】 Objective To study the relationships between Serum Cholinesterase Measurement of critical care patients and Acute Physiology and Chronic Health Evaluation Ⅱ. Methods The levels of serum cholinesterase in 116 critical care patients and 30 normal people were detected with colorimetric method to find their difference. A severity of illness score (APACHE Ⅱ) was determined for each patient during the first 24 h in the EICU , at the same time , serum cholinesterase were measured. First, these patients were divided into three groups based on their different scores and then were divided into two groups based on their prognosis : survival group and death group. Results (1) The serum cholinesterase levels in critical care patients were markedly lower than those in normal people (P < 0.01).(2) The serum cholinesterase levels in critical care patients were negatively correlated with APACHE Ⅱ score(r=-0.2251, P <0.01).Conclusions The serum cholinesterase level might be an important index reflecting the critical care patient’s condition , and an index for estimation of the prognosis.更多还原