【作者】 时昭红； 张书； 郝建军； 冯云霞； 陈洲；

【Author】 SHI Zhao-hong ZHANG Shu HAO Jian-jun FENG Yun-xia CHEN Zhou (Wuhan Chinese and western medicine hospital,wuhan 430022,China)

【机构】 武汉市第一医院消化内科；

【摘要】 目的研究微米大黄炭对大鼠血小板功能的影响。方法以 SD 大鼠为研究对象, 将动物分为微米大黄炭大、中、小剂量组,阳性对照组和空白对照组5组,给药6天后,测定大鼠血小板聚集性及血栓素 B-2（TXB₂）和6-酮一前列腺素 F_1α(6-keto-PGF_1α)、血小板颗粒膜蛋白-140（GMP-140）的含量。结果微米大黄炭能够显著提高血小板聚集性,提高 TXB₂ 而下调6-keto-PGF1α的水平,较空白对照组有统计学意义,而微米大黄炭大剂量组作用优于云南白药（P＜0．05）；用药各组均能提高大鼠血浆中 GMP-140的含量（P＜0．05）,微米大黄炭大剂量组有显著统计学意义（P＜0．01）。结论微米大黄炭可能是通过对 TXB₂、6-keto-PGF1α含量的影响来实现对血小板活化作用的调节,从而增强血小板的黏附和聚集功能,促进凝血, 作用优于云南白药。更多还原

【Abstract】 Objective To study the effects of micron rhubarb charcoal on the Function of Blood Platele in rats.Methods SD rats were divided into contral gruop、Yunan Baiyao group and micron rhubarb charcoal high、normal and low dosage gruop,ig six days.We studied the effects of micron rhubarb charcoal on platelet aggregation,TXB₂、6-Keto-PGF_1A and GMP-140 in SD rats.Results The results indicated that compared with normal rats,the micron rhubarb charcoal increased Platelet aggregation and the level of TXB₂,then decreased the level of 6-Keto-PGF_1A（P＜0.05）.thereinto,the effect of high dosage of micron rhubarb charcoal was bettet than Ytman Baiyao （P＜0.05）;compared with normal rats,other groups were increased the level of GMP-140 in blood plasma of rats.Conclusion The main hemostasia mechanism of micron rhubarb charcoal was to increased Platelet aggregation by affecting the level of TXB₂ and 6-Keto-PGF_1A, The effects of hemostasia is better than Yunan Baiyao。更多还原