【作者】 陈远岭； 张大千； 施剑飞； 唐文新； 曹阳光；

【Author】 Chen Yuanling, Zhang Dajian, Zhu Yaohua, et al: Zhabei Mental Health Centre of Shanghai, 741-18 Gaoping Road, Shanghai City 200436, CHINA

【机构】 温州市康宁医院心身科； 镇江市第四人民医院； 杭州市第七人民医院；

【摘要】 目的:本项研究通过对一组抑郁症患者发作期和恢复期的DAS评定,并以精神分裂症和正常健康人群作对照,以期能说明:抑郁患者的认知障碍是与抑郁严重程度相关的状态依从性症状?还是导致抑郁产生及容易复发的特征性因素之一?方法:应用“功能失调性状况评定量表(DAS)”、“Beck抑郁白评量表(BDI)”和“Hamilton抑郁量表 (HAMD)”对84例抑郁症、94例精神分裂症和100例正常人进行对照研究。结果:抑郁症患者经过药物治疗,临床抑郁症状改善明显,BDI测分治疗前后有明显差异(P<0．01)。但有关患者认知功能的改善情况,除了少数与抑郁关系较为密切的认知因子在治疗前后有差异外,大多数认知因子及DAS总分在治疗前后无明显差异。治疗后(恢复期)的抑郁症患者与正常人相比,BDI评分无明显差异,但DAS总分及大多数认知因子分有明显差异(P<0．01)。说明药物治疗虽然减轻了抑郁症状,但抑郁症患者的认知障碍并末明显改善。结论:我们的研究结果可以初步证明,功能失调性状态可作为抑郁症的一个特征性心理状态,认知障碍是抑郁症的一种素质因素,构成了抑郁的易患性。更多还原

【Abstract】 Objective: To investigate the relationship between cognitive dysfunction and depressive disorders. Methods: Seventy-five patients with depression were assessed with Dysfunctional Attitudes Scales(DAS), Beck Depression Investigatory Scale(BDI) and Hamilton Depression Scale(HAMD).The control groups with the same assessment were include in the study: ninety-four patients with schizophrenia and one hundred normal subjects. Results: Compared with three groups after systematic statistic analysis, the results suggested that the depression seems to have the specific cognitive patterns, depressed patients had more dysfunctional attitudes than did control subject. With remission of depressive symptom after pharmacotherapy alone, but the increased score on DAS continued to persist. Conclusion: Cognitive dysfunction in depressive patients that construct a vulnerability of depression seen more traitlike.更多还原