【作者】 李黎波； 罗荣城； 张鸣江； 罗宇玲； 缪景霞；

【Author】 Li Li-Bo Luo Rong-Cheng Liao Wang-Jun Zhang Ming-Jiang Luo Yu-Ling Miao Jing-Xia Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China

【机构】 南方医科大学南方医院肿瘤科；

【摘要】 目的:探讨PHOTOFRIN光动力治疗晚期鼻咽癌以观察其近期疗效及毒副反应。方法:30例肿瘤患者均属于临床IV期,分为光动力治疗组和化疗组两组,光动力治疗组光敏剂为PHOTOFRIN,按2mg／kg体重静脉滴注,48小时后经内镜导入光导纤维给以630nm的激光照射,48h后经内镜清除坏死组织并对原有病灶和新发现病灶给以复照,之后根据具体情况给患者的病灶部位清除坏死组织。化疗组给以常规顺铂和5-氟脲嘧啶化疗。结果:光动力组总有效率(78． 6％)和腔道梗阻的缓解率均明显高于化疗组,KPS评分也有明显差异。结论:与常规化疗相比光动力治疗晚期鼻咽癌能够有效的解除腔道梗阻,毒副反应轻,耐受性好,明显改善患者的生存质量,对晚期鼻咽癌不失为一种较好的姑息治疗手段。更多还原

【Abstract】 Objective: To evaluate the clinical efficacy and adverse effects of photofrin photodynamic therapy (PDT) in patients with nasal pharyngeal cancer under endoscope. Methods: 30 patients with nasal pharyngeal cancer were devided into two groups as PDT group and chemotherapy group. In PDT group, the patients received intravenous administration of photofrin as the photosen-sitizer at the dose of 2 mg/kg b.w. 48 h before PDT by 630 nm light (DIOMED) delivered through cylinder diffusing tip quartz fibers that passed through the biopsy channel of a flexible endoscope. PDT endoscopy was repeated, the necrotic tissue removed and, if necessary, the primary sites ’and other newly identified sites were subjected to a second exposure 48 h later. Endoscopy was repeated one month after PDT and periodically thereafter as needed to evaluate. The routine DDP and 5-Fu were given in the chemotherapy group. Results The total remission rate (78.6%) and nasal cavity obstruction remission rate in PDT group was better than that in chemotherapy group significantly. And the KPS score was also significant difference. Conclusion: Photofrin PDT is effective and safe in the treatment of late nasal pharyngeal cancer compared with routine chemotherapy, which may be a good appeasement method of advanced stage cancer which can be controlled by routine methods.更多还原