Novel Isatin Modified Peptides as SARS 3C-like Proteinase Bifunctional Inhibitors

【作者】 周璐； 金凤； 郑腾飞； 刘莹； 来鲁华；

【Author】 Lai Luhua Liu Ying Beijing National Laboratory for Molecular Sciences,State Key Laboratory for Structural Chemistry of Unstable and Stable Species,College of Chemistry and Molecular Engineering,Peking University,Beijing 100871

【机构】 Beijing National Laboratory for Molecular Sciences,State Key Laboratory for Structural Chemistry of Unstable and Stable Species,College of Chemistry and Molecular Engineering,Peking University；

【摘要】 <正>The 3C-like protease of severe acute respiratory syndrome(SARS)coronavirus has been proposed to be a key target for structural based drug design against SARS.The dimer of the protease is the major form for biological activity therefore the dimeric interface could also be targeted for structural-based更多还原