【作者】 弓建红； 陶京朝； 杨云；

【Author】 Gong jianhong1 ,Tao jingchao2 ,Yang yun1 1. Henan college of TCM, Zhengzhou ,450008; 2. Derpartment of Chemistry, .Zhengzhou University, Zhengzhou, 450052

【机构】 河南中医学院药学院； 郑州大学化学系；

【摘要】 目的寻找价格低廉的催化剂用于手性1,2-二苯基-2-氨基乙醇及其衍生物的配体的合成。方法以Raney Ni作为催化剂,将安息香肟催化氢化合成1,2-二苯基-2-氨基乙醇,考察了温度,压力对反应的影响。结论最终得到收率较高赤式和苏式非对映体混合物。经分步结晶,分别得到纯度较高的赤式和苏式非对映体。更多还原

【Abstract】 OBJECTIVE The catalytic hydrogenation of benzoin oxime to 1, 2-diphenyl-2- amino alcohol with Raney Ni or Pd-C as catalyst is studied. METHODS methods are studied from the reactional conditions which brings to great infections for the products and the yields. RESULTS The erythro- and threo-diastereo mixture is formed simultaneously when Raney Ni is used as catalyst whereas only ethreo-racemic products are obtained in the condition of Pd-C.更多还原