【作者】 刘默； 刘颖； 刘登科；

【Author】 Liu Mo*, liu Ying, Liu Deng-ke (Tianjin Institute of Pharmaceutical Research, tianjin 300193, China)

【机构】 天津药物研究院药物创新研究中心；

【摘要】 噁唑烷酮类抗菌药是一类新型化学全合成抗菌药,具有抑制多重耐药革兰氏阳性菌的作用。该类化合物的代表药物利奈唑酮对革兰氏阳性菌以及多重耐药的病原体抗菌活性较好,耐受性良好。本文综述了噁唑烷酮类抗菌药的作用机制、抗菌活性、构效关系及其国内外研究进展情况。更多还原

【Abstract】 The totally-synthetic oxazolidinones are a new class of antibacterial agents for the treatment of the infections caused by Gram-positive bacteria including the Multi-drug-resis- tant pathogens. Linezolid is the typical compound of oxazolidinones, which has been launched into international market. It has a broad antibacterial spectrum against Gram-positive organisms including multi-drug-resistant pathogens. The emphasis has been paid on mechanism of action , antibacterial activity, structure-activity relationship and the new development in research..更多还原