【作者】 吴惠丰； 孙国英； 张晓宇； 吴亦洁； 裴奉奎；

【Author】 Huifeng Wu Guoying Sun Xiaoyu Zhang Yijie Wu Fengkui Pei Laboratory of New Drug Research,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun,130022,E R.China

【机构】 中国科学院长春应用化学研究所；

【摘要】 <正>近年来高分辨率~1H NMR 技术结合模式识别(PR)方法在生物体液中代谢物的研究,得到了长足的发展,尤其在临床医学应用和药物毒性分类领域显示出重要的作用。随着稀土化合物的广泛应用,稀土元素有可能越来越多地通过各种途径进入生物体内,因此评价稀土在生物体内所造成的短期和远期生物效应,并对稀土的安全用量做出科学的评价已成为重要更多还原

【Abstract】 Pattern recognition technique has been appfied to the studies of 600 MHz ¹HNMR spectra of urine from rats treated with Lu（NO₃）₃.Male Wistar rats administered with variable dosages（0.2,2, 10,100 mg/kg body weight）of Lu（NO₃）₃ and one of the following model compounds:sodium chromate,mercury Ⅱ chloride,hydrazine,carbon tetrachloride,α-naphthylisothiocyanate,or vehicle.Urine samples were collected over a 48 hour time-course and the ¹H NMR spectra were measured on a 600 MHz spectrometer.The NMR data were analysed by Soft Independent Modelling of Class Analogy（SIMCA）.Successful classifications of the acute biological effects of Lu（NO₃）₃ were achieved based on the model compounds.更多还原