【作者】 韩丹； 张先荣； 唐岳枫； 刘买利； 尹世金；

【Author】 Dan Han~(**) Xianrong Zhang Yuefeng Tang~1 Maili Liu~1 Shijin Yin Department of Physiology,Hubei Medical University,Wuhan 430071 Laboratory of Magnetic Resonance and Atomic and Molecular Physics,Wuhan Institute of Physics and Mathematics,The Chinese Academy of Sciences~1,Wuhan 430071

【机构】 湖北医科大学生理学教研室； 中国科学院武汉物理与数学研究所波谱与原子分子物理国家重点实验室；

【摘要】 <正>目的与方法：本工作的目的在于探讨中部颞叶新皮质（medial temporal lobe neocortex MTNC）-海马（hippocampus HPC）神经通路在颞叶癫痫发生、发展中的作用。慢性电刺激大鼠 MTNC 和背侧 HPC,一天一次,持续8-10天。测定动物行为发作频率、首次与末次脑电图以及 T₂-加权象核磁共振（T₂-weighted magnetic resonance imaging T₂-WI）成象。分别在强直电刺激 MTNC 的第2、4、6、8、10天进行 T₂-WI 的检测与行为发作频率进行比较。更多还原

【Abstract】 Aim and methods The purpose of the present work is to study the role of the MTNC--HPC neural pathway in temporal lobe epileptogenesis.Chronic tetanus into the HPC or MTHC were admmistrated once a day to establish temporal lobe epilepsy model.EEG and depth electrographes were recorded at the beginning and the end of cxperiments.T₂-WI was measured at stimulating day 7. Results Primary wet dog shakes,secondary WEDS and partial kindling effect were observed at chronic stimulating day 7～10. EEG and depth electrographic seizures in the MTNC or HPC were induced by tetanus before the end of experiments Compared with unchanged signal intensity in the same area in control sham rats,the brain images of experimental rats appeared higher signal intensity in the lateral ventriculus（LV）with T₂- WI,but the same changes did not found in any other brain area on visual analysis. The increase of T₂-WI intensities were paralleled to enhanced frequency of WEDS in the dorsal HPC stimulated rats（n=12）,which occurred unilaterally or bilaterally.In the MTNC stimulated rats hyperintensity in T₂-WI in contralateral LV related to the lower frequency of primary WEDS.These T₂-WI abnormalities began at stimulating day 4 in the MTNC stimulated rats（n=14）. Conclusion Over-activated MTNC might induce the disfunction of the HPC and resulted in epileptogenesis,which resembled to that happened in the dorsal HPC stimulated rats.It suggested that the HPC might be epileptogenic focus in the MTNC-EC-HPC neural pathway.更多还原