【作者】 方怡鸥； 刘雪辉； 崔育新； 许鹏飞；

【Author】 Fang Yi’ou Liu Xuehui Cui Yuxin (National Laboratory of Natural and Biomimetric Drugs,Medical and Health Analysis Center,Peking University,Beijing 100083) Xu Pengfei (Department of Chemistry,Lanzhou University,Lanzhou 730000)

【机构】 北京大学天然药物及仿生药物国家重点实验室医药卫生分析中心； 兰州大学化学系；

【摘要】 <正>我们对合成的十个6-芳基-3-辛可芬基-1,2,4-三唑[3,4-b]-1,3,4-噻唑类化合物进行了 NMR 研究,确定了其结构,为进一步研究这类化合物的构效关系打下了基础。该类化合物溶解性很差,几经尝试,最终使用三氟乙酸-d 作为溶剂。该溶剂可能对化合物的化学位移产生较大的溶剂效应,因此该类化合物在其它溶剂中的 NMR 实验数据与本数据对比时应考虑溶剂效应的影响。更多还原

【Abstract】 We obtained ¹³C and ¹H spectra of a group of 6-aryl-cinchophen-1,2,4-triazole[3,4-b]-1,3,4- thiazole which were newly synthesized.The ¹H and ¹³C spectra of these compounds are heavily overlapped.So we selected one compound and obtained its 2D NMR spectra（gCOSY,gHMQC, gHMBC）.We assigned all ¹H and ¹³C signals of this compound by the information gotten from its 2D NMR spectra.The assignments of the other compounds were done by comparing their different substituents.We also discussed the effects of different substituents on ¹³C chemical shifts.更多还原