【作者】 何志秀； 刘来奎； 陈艳；

【Author】 He Zhixiu Lin Laikui Chen Yan Department of Oral Pathology, West China College of Stomatology, Si Chuan University

【机构】 四川大学华西口腔医学院；

【摘要】 <正>为了探讨儿童口腔尖锐湿疣的病毒类型、传播途径、临床病理特点及预后等,本研究对6例确诊为口腔粘膜尖锐湿疣的儿童的临床特点及病理切片进行回顾,并对其中5例采用免疫组织化学染色和原位杂交检测HPV、HPV16／18、HPV6、HPV11。结果表明:儿童尖锐湿疣多发生在2岁左右。发病部位多位于腭部,并且多数具有家族史。光镜下特点为口腔粘膜呈乳突状增生,棘层上更多还原

【Abstract】 Condyloma acuminatum(CA)is a benign papillary lesion that is caused by the Human papillomavirus(HPV).In abult,the anogenital area is the most commonly affected site,but CA of the oral cavity,especially in child,are rarely found.Recently, 6 instances of oral condylomas of child have been found in our department. We review clinical character and slides of HE of 6 case which have been diagnosed as CA of oral mucosa, and adopted an Immunohistochemistry(IHC) and In situ hybridization(lSH) to detect HPV DNA. The result of this study show the lesion often appeared in 2 years and the most common location was hard or soft palate. Most of those families have even been infected by HPV. Kolicytes were common in upper spinous and corneal layers. HPV common antigen could be detected in all instances. In 4 of 5 instances HPV16/18-E6 antigen is positive. The result of ISH only show one case is positive for HPV6 and HPV11,the other case is positive for HPV6 that is negative after recurring. This study provides further confirmation of possible different genotype and transmisson in oral CA of children and adults.更多还原