【作者】 张勇； 陈煜； 杨新林； 孟薇薇； 谭惠民； 李杰； 蒋建新； 侯淦泉；

【Author】 Zhangyong, Chenyu, Yangxinlin, Mengweiwei, Tanhuimin, Lijie, Jiangjianxin, Houganquan (Beijing Institute of Technology, School of Life Science & Technology, Beijing 100081; Beijing Institute of Technology, School of Material Science & Engineering, Beijing 100081; State Key Laboratory of Trauma Burns and Combined Injury, The Third Military Medical University, Chongqing 400042)

【机构】 北京理工大学生命科学与技术学院； 北京理工大学材料科学与工程学院； 第三军医大学创伤、烧伤复合伤国家重点实验室；

【摘要】 <正>通过壳聚糖的水溶性衍生物羧甲基壳聚糖的接枝共聚反应,制备了新型壳聚糖基可吸收材料(Ab-CTS)。采用FT-IR对产物的结构进行了表征,采用TG对产物的热稳定性进行了研究。考察了反应条件,电解质溶液的类型,电解质溶液的浓度,溶液的pH值等对所制备的材料吸收液体性能的影响。对该可吸收性材料应用于动脉大出血的快速止血材料领域进行了初步探索,对其止血性能和生物相容性进行了研究。建立了新西兰白兔耳创面(包含耳动脉)、股动脉、脾脏的止血更多还原

【Abstract】 The absorbable chitosan material was prepared through graft copolymerized reaction of carboxymethyl chitosan . The structure of the product was characterized through FT-IR, The thermal stability of product was studied by means of TG, The relations of imbitition ability and condition of reaction, the type and concentration of electrolytic solution and pH of the solution were studied. This thesis aims to apply absorbable chitosan material to fast hemostatic fields and study primarily on its hemostatic properties and biocompatibility. The hemostatic models of ear artery, femoral artery, spleen of New Zealand rabbits were applied to study the hemostatic properties of the absorbable chitosan material. We find that this material could be hard adhered to the wound and have a good hemostatic properties, The hemostatic time for the absorbable chitosan material was short of the control groups (P<0.05). Moreover, after usage this material, the wound’s surface recovers well. The biocompatibilities of the absorbable chitosan material were studied through the skin stimulation test and acute systemic toxicity test. We find this material had no skin stimulation and acute systemic toxicity reaction.更多还原