【作者】 王芳； 杨振军； 张亮仁； 张礼和；

【Author】 Fang Wang, Zhen-Jun Yang,* Liang-Ren Zhang, Li-He Zhang The State Key Laboratory of Natural & Biomimetic Drugs, Peking University, 100083

【机构】 北京大学医学部天然药物及仿生药物重点实验室；

【Abstract】 Nucleoside analogues play an important role in antiviral and anticancer chemotherapy. Isonucleoside, a class of nucleoside analogues in which the nucleobase is linked at various positions of ribose other than C-1’, has attracted much attention owing to its chemical and enzymatic stability and potential antivital and anticancer activities. Amino is an important functional group in physiological conditions. Nucleotides containing amino group can minimize the electrostatic repulsion between the anionic sense and the Zwitterionoc antisense cords, thus the stability of oligonucleotides could largely increased. Here we describe the synthesis of some amino isonucleosides from D-glucose.更多还原