【作者】 程卯生； 闫茂才； 刘洋；

【Author】 Mao-Sheng Cheng*, Mao-Cai Yan, Yang Liu School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 110016, Shenyang

【机构】 沈阳药科大学制药工程学院,辽宁省药物设计与评价重点实验室；

【Abstract】 Triterpenoid saponins are an important family of natural products. It has been found that many triterpenoid saponins bearing α-L-rhamnopyranosyl-(1->2)-α-L-arabinopyranosyl moiety generally have significant antitumor activity. We accomplished the synthesis of two typical triterpenoid saponins with this substructure, β-hederin (1) and hederacolchiside A1 (2), and evaluated their bioactivity thereafter. Lotoidoside D (3) and E (4) are two saponins bearing N-acetylglucosamine discovered from roots of Glinus lotoides, and were found to have antiproliferative activity against WEHI-164 cell. We synthesized them from easily available oleanolic acid, and pharmacological showed their antitumor activity to HeLa cell.更多还原