【作者】 张文翠； 尹立红； 浦跃朴； 刘冉； 胡旭； 刘耀珍；

【Author】 Zhang Wencui, Yin Lihong, Pu Yuepu, Liu Ran, Hu Xu, Hu Yaozhen(School of Public Health, Southeast University, Nanjing 210009,China; Chuzhou Center for Disease Prevention and Control, Huaian 223200, China)

【机构】 东南大学公共卫生学院； 江苏省淮安市楚州区疾病预防控制中心；

【摘要】 [目的] 研究DNA修复基因XPA(A23G)、XPD(Lys751Gln)、XRCC1(Arg194Trp和Arg399Gln)多态性与食管癌易感性的关系。[方法] 通过1:1配对的病例-对照研究研究方法收集样本106对,应用PCR-RFLP技术检测样本的基因型,比较不同基因型与食管癌易感性的关系。[结果]携带XPA G/G基因型的个体与携带A/A基因型者相比,可降低患食管癌的危险性(OR=0.4737,95%CI=0.2280-0.9839);食管癌组中,携带XRCC1 399(Gln/Gln)的个体数高于对照组,其患食管癌的危险性是对照人群的3倍(OR=3.447,95%CI=1.078-11.026,P=0.029)。含有XPD 751 Gln、XRCC1194Trp等位基因的个体其患食管癌的易感性未见显著性升高(OR=1.424,95%CI=0.621-3.263;OR=0.826,95%CI=0.857-1.381)。[结论]DNA修复基因XPA 23位和XRCC1 399位多态可能在食管癌的发生中起一定作用。更多还原

【Abstract】 [Objective] To explore the relationship between the polymorphisms of XPA (A23G), XPD (Lys751Gln), XRCC1 (Arg194Trp and Arg399Gln) genotypes and susceptibility to esophageal cancer in Huai’an population, China. [Methods] A 1:1 case-control study was conducted among 106 ESCC patients and 106 control subjects (matched by age±5 years and gender). PCR-RLFP method was used to detect genotypes. [Results] There was significant difference of distribution of mutant homozygote of XPA 23 and XRCC1 399 genotype between cases and controls (X2=4.0277,P=0.0448; X2=4.745, P=0.029, respectively). Individuals with mutant allele of XPD 751 or XRCC1 194 genotype do not show the rising risk of esophageal cancer (OR=1.424, 95%CI=0.621-3.263; OR=0.826, 95%CI=0.857-1.381, respectively). [Conclusion] The results showed that the polymorphisms of XPA A23G and XRCC1 Arg399Gln were related to the susceptibility of esophageal cancer.更多还原