【作者】 闫志晖； 赵子彦；

【Author】 Yan Zhi-Hui, Zhao Zi-Yan (Anti-Senility Research Center of Shandong, Shandong Academy of Medical Sciences, Jinan,250062,China)

【机构】 山东省医学科学院抗衰老研究中心；

【摘要】 调节哺乳动物生物钟的光感受器是目前生物学研究的热点之一。2001年冬季《Science》报导了研究者们在大鼠的眼内首次发现了一类新的直接联接大脑生物钟中枢(视交叉上核)具有感光性的视网膜神经节细胞,并在这类细胞内发现了一种与视觉成像无关的感光色素,被命名为视黑质(或者称作黑视蛋白,Melanopsin)。这些含有视黑质的视网膜神经节细胞可能就是调节哺乳动物脑生物钟的光受体细胞,使哺乳动物的昼夜节律生物钟与外界环境保持同步。以下简介关于视黑质和视网膜光受体细胞的研究进展。更多还原

【Abstract】 One of the hotspots in biological research is the research on retina photoreceptors that regulate circadian rhythms entrained to light cycles in mammalians. In winter of 2001, researchers reported in Science of the discovery of a brand-new class of light-responsive cells in retinal ganglion cells(RGCs) in the eyes of rats that connect directly to brain’s clock center (the suprachiasmatic nucleus), and a pigment called melanopsin that mediate non-visual photoreception was found in these cells. These melanopsin-containing RGCs may contribute to regulation of circadian rhythms entrained to light cycles in mammalians. We reviewed briefly the recent progress of studies on melanopsin and retina photoreceptors.更多还原