【作者】 于多； 王芳； 何颖； 李经才；

【Author】 YU Duo, WANG Fang, HE Ying ,LI Jing-Cai (Chronobiology Laboratory, Shenyang Pharmaceutical University, Shenyang 110016)

【机构】 沈阳药科大学时间生物学研究室；

【摘要】 生物钟基因普遍存在于生物界,其作用在于产生和控制昼夜节律的运转。生物钟基因及其编码的蛋白质组成反馈回路,维持振荡系统持续进行并与环境周期保持同步。各级进化水平物种生物钟的基因组成和控制途径有同有异。本文主要介绍蓝细菌、脉孢菌、果蝇、鼠和人昼夜钟的分子运作机制以及研究钟基因的意义和展望。更多还原

【Abstract】 The circadian clock genes, which generate and control the running of the circadian rhythms, exist in organisms ranging from prokaryotes to mammals. The oscillator genes and its coding proteins compose the feedback loops of circadian system. The kind, number and regulating route of clock genes are characterized by living things at different evolution levels. The molecular mechanism of the run of circadian clock genes in cyanobacteria, neurospore, fruit fly, mouse and human being is introduced in this article.更多还原