【作者】 王月英； 周则卫； 沈秀； 王汝勤； 张良安；

【Author】 Wang Yueying, Zhou Zewei, Shen Xiu, Wang Ruqin, Zhang Liangan (Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Tianjin, 300192,China)

【机构】 中国医学科学院、中国协和医科大学放射医学研究所；

【摘要】 目的观察抗辐射药物E838对IRM-2小鼠、ICR小鼠的辐射防护作用,为研究新型抗辐射药物提供动物模型。方法照射前3、2、1d腹腔注射药物,对照组腹腔注射茶油,分别经¹³⁷Csγ射线8.0 Gy全身一次性照射后,观察小鼠30 d生存天数。结果IRM-2小鼠100μg/0.2 ml、150μg/0.2 ml、200μg/0.2 ml存活率与对照组比较分别提高55%、75%、85%,ICR小鼠提高35%、30%、20%。结论E838对受γ射线照射小鼠有一定的防护作用。IRM-2近交系小鼠辐射抗性明显高于ICR小鼠,是研究抗辐射药物最佳动物模型。更多还原

【Abstract】 Objective To examine the Radiation Protective Effect of E838 on IRM2 mice irradiated with γ-ray . Methods IRM-2 and ICR mice were injected iv respectively with 100 μg, 150 μg, 200 μg of E838 at 3 d, 2 d and 1 d before irradiation, then were irradiated by 8 Gy 137 Cs γ-ray with dose rate 0.87 Gy/min, The Survival rate in 30 d were examined. Results Survival rates of IRM-2 for 100 μg, 150 μg, 200 μg were 55% , 75% , 85% , respectively. These were 35% , 30% and 20% higher than those of ICR mice. Conclusion E838 has some Radiation Protective Effect on mice, IRM-2 mice have higher Radiation resistance than ICR mice.更多还原