【作者】 丁吉新； 宋海波； 杨佩琨；

【Author】 DING Ji-Xin, SONG Hai-Bo, YANG Pei-KunShandong Province New Drugs Pharmacological Research Center, Jinan 250100, China

【机构】 山东省新药药理研究中心；

【摘要】 目的:观察低分子量肝素钠（Low molecular weight heparin,LMWH）在大鼠动静脉旁路血栓模型上的抗血栓形成作用和对家兔凝血、纤溶系统的影响。方法:用大鼠动静脉旁路血栓模型观察LMWH的抗血栓形成作用,常规方法测定LMWH对家兔血浆凝血酶原时间（PT）,凝血酶时间（TT）、部分凝血活酶（KPTT）的影响,对纤维蛋白原（Fg）含量和优球蛋白溶解时间（ELT）的影响。结果:LMWH sc 343、686和1372 anti-Xa IU/kg后,对大鼠动静脉旁路血栓形成呈剂量依赖性抑制,以血栓百分抑制率计算LMWH的ED₅₀为1115IU/kg。LMWH sc 172、343、686 anti-X a IU/kg后,对PT、TT都有延长作用,对KPTT除个别时间点有影响外,其余无明显影响。LMWH中、高剂量组均降低Fg含量,在药后60-90min内明显缩短了ELT。结论:LMWH抗血栓形成作用明显强于SH,且对凝血系统影响比SH小,而对纤溶系统的影响,LMWH明显强于SH。更多还原

【Abstract】 Low Molecular Weight Heparin (LMWH) was obtained by controlled nitrous acid degradation of standard heparin(SH). It was demonstrated that 1) LMWH had less effect on coagulation system than SH. 2) The effects of LMWH and SH on thrombosis in vivo were similar to each other. The ED50 of LMWH in model of artero-venous shunt was 1115 Xa IU/kg. 3)The effect of LMWH on fibrinolysis system was more power than SH. The findings suggest that LMWH remains the anti-thrombotic effect of SH,and is a potential anti-thrombic agent.更多还原