【作者】 王琦； 任东青； 邝芳； 孙敬民； 王晋； 庞轶兵； 郭鹞； 郭国祯；

【Author】 Wang Qi, REN Dong-Qing ,Kuang Fang,Sun Jing-Min,Wang Jin.Pang Yi-Bing. GUO Yao, GUO Guo-Zheng,(Fourth Military Medical University: Department of Radiation medicine, Institute of Neuroscience, Xi’ an 710032, China)

【机构】 第四军医大学预防医学系放射医学教研室； 第四军医大学神经生物研究所；

【摘要】 目的:研究脉冲式电磁辐射(EMR)对大鼠血脑屏障(BBB)影响量效关系。方法:采用伊文思蓝静脉注射,荧光显微镜下观察不同脉冲次数的EMR辐照对大鼠BBB开放的影响。结果:伊文思蓝在EMR诱发的大鼠BBB开放局部呈现荧光斑:随着EMR脉冲次数(0-200次)的增加,荧光斑数量增加、面积增大;荧光斑在EMR组全脑的分布,以皮质、丘脑、下丘脑、小脑、尾壳核和延髓较多。结论:不同脉冲次数EMR诱发大鼠BBB开放程度不同,随脉冲次数增加,血管通透性增强,200次时达开放高峰,皮质区BBB开放最明显。更多还原

【Abstract】 AIM To investigate the dose-effect relationship of Electromagnetic radiation on rat Brain-blood-barrier. METHODS In this study, EB was used on the rat by intravenous injection, then through fluorescent microscope to observe the effects of EMR in different pulses. RESULTS EB can form fluorescent faculae in brain where the rat BBB permeability had changed; the figure and area of fluorescent faculae increased along with pulse numbers (0-200 pulses). Fluorescent faculae in EMR group were distributed over the rat brain, in cerebral cortex, thalamus, hypothalamus, cerebellum, caudate putamen and mudulla oblongata. CONCLUSION Pulsed EMR in different sequence can induce different quantitative changes of BBB permeability in rat brain, at 200 pulses the change is the most obvious, the cerebral BBB permeability changed more than the other.更多还原