节点文献
电磁脉冲引起细胞膜电穿孔诱发细胞凋亡和提高抗癌药物细胞毒性
Induction of Apoptosis by Electroporation and Study of Higher Cytotoxity of Anticancer Drugs Due to Electroporation
【Author】 WangBao-yi Zhang Hong (College of Electron Information, Sichuan University, chengdu 610064)Sun Jing-ru Wang Zi-shu (College of Life Science.sichuan University, chengdu 610064)
【机构】 四川大学电子信息学院； 四川大学生命科学学院；
【摘要】 报道了电穿孔可以诱发HeLa细胞凋亡,采用Gigmsa染料、吖啶橙染色及Hoechst33342,PI双染色,研究了电穿孔对HeLa细胞凋亡的影响。以HeLa细胞和胎儿脐带血淋巴细胞为材料,进行了电穿孔提高抗癌药物细胞毒性的研究,为电化学疗法在体内实验的可行性提供了依据。
【Abstract】 That electroporation can induce apoptosis is investigated in HeLa cells, the effects of electroporation to apoptosis of HeLa cells is studied with Giemsa, Acridine orange,Hoechst33342 and propidium iodide staining. HeLa cells and fatal navel cord blood lymphocytes are chosen as research objects in the experiment, which determines whether or not electroporation can enhance cytotoxity of anticancer drugs The results can testify the feasibility of electrochemotherapy (ECT) trials in vivo.
- 【会议录名称】 第十二届全国电磁兼容学术会议论文集
- 【会议名称】第十二届全国电磁兼容学术会议
- 【会议时间】2002-10
- 【会议地点】中国天津
- 【分类号】R35
- 【主办单位】中国电子学会电磁兼容分会、中国通信学会电磁兼容委员会