【作者】 王哲海； 冯斌；

【Author】 Wang zhe-hai, Feng bin Department of internal medicine, Shandong Tumor Hospital. Jinan 250117, P.P.China

【机构】 山东省肿瘤医院内科；

【摘要】 抗肿瘤药物的细胞毒作用在每日24小时不同的时间给药波动幅度可达50%.其发生机制与细胞代谢过程及药物的药代动力学的昼夜节律性变化有关.在此基础上产生了肿瘤时间化疗这一前沿性学科.本文试图对近年来时间化疗所常用的药物、所治疗的肿瘤等状况进行简要综述.更多还原

【Abstract】 The cytotoxicity of more than thirty anticancer drugs varies by more than 50% as a function of dosing time along the 24-h time-scale in laboratory animals. Mechanisms involve circadian changes in cellular metabolism and proliferation processes, as well as drug pharmacokinetics. These variations have warranted the exploration of the relevance of the cancer chronotherapy principle. The common drugs used in cancer chronotherapy and the treatment state of some cancers with chronotherapy are briefly reviewed in this article.更多还原