【作者】 朱慧琴； 谢匡成； 陈玲娣； 朱光斗；

【Author】 ZHU Huiqin.XIE Kuangcheng,CHEN Lingdi, ZHU Guangdou.Department of DermatoIogy,Shanghai First People’ s Hospital, Shanghai 200080

【机构】 上海市第一人民医院皮肤科；

【摘要】 目的 探讨中国人（汉族）维生素D受体（VDR）基因多态性与银屑病的关系。 方法 采用聚合酶链反应和限制性内切酶酶切技术（PCR-RFLP）,对112名无血缘关系的银屑病患者和108名无血缘关系的健康人员的VDR Apα1的位点基因型进行分析,并采用卡方检验的方法对结果进行分析处理。 结果 银屑病患者与健康人的VDR Apα1位点基因型的分布情况有非常显著的不同,AA基因型在健康人中出现的频率很低,仅7.4％,而在银屑病人中出现的频率明显增高,为19.6％。进一步分析VDR基因型与银屑病患者性别、发病年龄、家族史等的关系,未发现显著相关。另外,在分别统计等位基因A、a时,发现它们在两组人群中出现的频率无显著差异。 结论 中国人维生素D受体（VDR）基因型分布在银屑病患者与健康人中是显著不同的。在中国人中,纯合子AA基因型的出现可能增加患银屑病的危险性。更多还原

【Abstract】 Objective To study the correlation between vitamin D receptor(VDR ) polymorphism and psoriasis in Chinese. Methods We used PCR-RFLP to determine VDR Apa 1 site genotypes in 112 unrelated psoriatic patients as well as in 108 unrelated healthy people. Differences in the VDR genotypes were compared between psoriatic patients and cotrols by chi square test. Results There was a singificant difference in VDR Ap α 1 site genotypes between psoriatic patients and normal controls. We found a significant increase in subjects carrying AA genogypes in psoriatic patients(19.6%)compared with those in normal controls(7.4%).However, sex,age at onset, family history of psoriasis did not show any singificant correlation with VDR polymorphism in psoriatic patients. In addition, there is no significant difference in the friquency of the A,a allele between normal controls and psoriatic patients. Conclusions Presence of homozygotes AA would increase the tendency to develop psoriasis.更多还原