【作者】 彭振辉； 耿松梅； 王俊民； 阎呼玲； 张秉正； 王香兰；

【Author】 Peng zhenhui, Geng songmei, Wang junmin, et al. Department of dermatology, Second hospital affiliated to Xi’ an Jiaotong University

【机构】 西安交通大学第二医院皮肤科；

【摘要】 目的 探讨银屑病中医分型本质。 方法 根据中医理论将22例银屑病患者分为血热型、血燥型、血瘀型3组,分别取患者典型皮损和血进行超微结构分析和血液流变学检测,并测定患者血中TGFβ、TNFα的生物活性。 结果 三型均有表皮细胞增殖和真皮血管周围炎症细胞浸润,血热型毛细血管扩张明显,血瘀型毛细血管管腔狭窄并血液粘度增高。三型TGFβ、TNFα的生物活性均低于对照,血热型TNFα抑制活性最强,与血瘀型、血燥型相比差别有显著性意义（P<0.001）。 　 结论 银屑病的中医分型与疾病的病理变化密切相关,细胞因子的变化可揭示中医分型中各型病变的转归机制。更多还原

【Abstract】 Objective To investigate the essence of the classification of psoriasis based on TCM. Method 22 cases of psoriasis patients were classified into three groups as heat-in-blood,dryness-in-blood,and blood-stasis based on TCM.Sera and biopsy lesions of patients were used to analyze the superstructure, blood flowing, moreover, biological activity of TGFβ, TNF α was determined through patients sera incubating with sensitive cell lines respectively. Results All types had same identities of epidermis proliferation and inflammatory cells infiltrating capillary,but capillary dilation was markedly in heat-in-blood,whereas,capillary stenosis happened in both other types, the biological activity of TGF β, TNF α in psoriasis patients was lower than that of the standard controls.TNF α of the heat-in-blood patients had the strongest inhibitive effects, the differences were significant(P < 0.001). Conclusions Classification of psoriasis in TCM is correlated with the pathogenesis of psoriasis, cytokins changing contributes to the transformation of clinaical TCM classification.更多还原