【作者】 黄莉； 赵德明； 庞万勇； 李强； 刘洁；

【Author】 Li Huang, Deming Zhao, Wanyong Pang, Qiang Li, Jie Liu (Veterinary medicine college, China Agricultural University Beijing 10094, China)

【机构】 中国农业大学动物医学院；

【摘要】 本文对犬骨髓性白血病的病例进行临床和病理组织学观察.该犬为长毛黑贝,消瘦,呈恶病质状态,血液化验结果为:RBC、HCT、HGB明显低于正常值,WBC显著高于正常值.血液涂片的观察结果为肿瘤细胞显著增加,核大小不一,分化程度不等,形状极度不规则,有圆形、椭圆形、镰刀形,还有菜花状、肾形、分叶形等.石蜡切片观察可见骨髓和淋巴结内有大量肿瘤细胞弥漫,肝脏、脾脏、肺脏中也有肿瘤细胞的广泛性浸润,这种肿瘤细胞核大且深染,核形状多以圆形、椭圆形为主,有时可见核分裂相,胞浆丰富.该病例综合诊断为犬骨髓性白血病.更多还原

【Abstract】 A case of Canine Myeloid Leukemia is met in the clinical practice. The dog is a German shepherd with weight loss, showing a state of cachexia. Results of the ordinary blood test are RBC 3.28 * 1012 /L, HCT0.274L/L, HGB 1.2g/L, WBC 501.6*109/L. The three values, RBC, HCT and HGB, are significantly lower than the standard value, while the value of WBC is conspicuously higher than the Standard one. Various tumor cells stages, mature or immature tumor cells, can be observed in the blood smears. The total number of tumor cells in the blood smears increase greatly Tumor cells mainly consist of myeloid cells which have abnormal, hyperchromic nuclei, nuclei shapes varying from round, band to irregular form. In addition, Leukocytes predominantly can also be observed in the bone marrow and lymphocytes slides, what’s more, leukocy tes scatter mother organs, for instance liver, lung and spleen. So myeloid leukemia may be diagnosed in this case.更多还原