【作者】 于芳； 李寅增；

【Author】 YU Fang, LI Yinzeng(Department of Laboratory Animal Science , Peking University Health Center, Beijing 100083, China)

【机构】 北京大学医学部实验动物科学部；

【摘要】 目的 了解普通级金黄地鼠感染状况.方法 普通级金黄地鼠10只,麻醉断髓处死,剖检.各主要脏器称重,计算脏器系数.各脏器制片,组织病理学镜检.结果 各只动物脏器均存在潜在感染;脏器的潜在感染出现率由高到低分别为:肝脏(9/10),肺脏(7/10),心脏(5/10),肾脏(4/10),脑(4/10);平均每只动物主要脏器(心脏、肝脏、肺脏、肾脏、脑)潜在感染的出现率为2.9例/只(2-5个/只);病变主要为各脏器可见淋巴样细胞浸润或伴有细胞、组织的变性坏死.结论 普通级金黄地鼠的净化势在必行.更多还原

【Abstract】 Objective Understand the infection situation of conventional golden hamsters. Methods 10 conventional female golden hamsters were sacrificed as soon as we get them. The organs ( heart, liver, lung, kidney and brain) were dissected and weighted. Calculated the visceral coefficient. Paraffin sections were made, stained with HE ( hematoxylin and eosin ), and examined histopathologically with microscope. Results Organs had latent infection in every animal. The infection mostly occurred in liver (9/10), then in lung (7/10), heart (5/10), kidney (4/10) and brain (4/10). The average of infection occurrence is 2.9 organs per animal (from 2 to 5 organs per animal). Lymphocytes influence or denaturation or necrosis were observed. Conclusion Golden hamster must be cleaned from conventional to clean.更多还原